GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs4660306 | 1 | rs2356559 | chr1:45981512 | CCDC163P | chr1:45960581-45965646:- | -0.53 | -7.3 | 1.47E-11 | Homocysteine levels |
| UCEC | cis | rs4660306 | 1 | rs2356561 | chr1:45980862 | CCDC163P | chr1:45960581-45965646:- | -0.47 | -6.38 | 2.0E-9 | Homocysteine levels |
| UCEC | cis | rs2239557 | 1 | rs2358628 | chr14:74631757 | LIN52 | chr14:74551656-74667117:+ | -0.29 | -4.42 | 1.88E-5 | Common traits (Other) |
| UCEC | cis | rs2360111 | 1 | rs2360111 | chr17:831667 | TIMM22 | chr17:900357-905388:+ | -0.35 | -4.62 | 8.26E-6 | Economic and political preferences |
| UCEC | cis | rs10935120 | 1 | rs2370641 | chr3:134222161 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.08E-6 | Height |
| UCEC | cis | rs10935120 | 1 | rs2370642 | chr3:134222136 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.63 | 7.74E-6 | Height |
| UCEC | cis | rs9815354 | 1 | rs2371623 | chr3:41761083 | ULK4 | chr3:41288091-42003660:- | 0.52 | 6.41 | 1.76E-9 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs2371627 | chr3:41839219 | ULK4 | chr3:41288091-42003660:- | 0.54 | 6.51 | 1.03E-9 | Diastolic blood pressure |
| UCEC | cis | rs2403083 | 1 | rs2403083 | chr8:86108149 | LRRCC1 | chr8:86019377-86058312:+ | 0.36 | 4.43 | 1.76E-5 | Plasma amyloid beta peptide concentrations (ABx-40) |
| UCEC | cis | rs12590640 | 1 | rs2415326 | chr14:36860447 | MBIP | chr14:36767764-36789882:- | 0.36 | 4.65 | 7.28E-6 | Malaria |
| UCEC | cis | rs12590640 | 1 | rs2415345 | chr14:36860506 | MBIP | chr14:36767764-36789882:- | 0.36 | 4.65 | 7.28E-6 | Malaria |
| UCEC | cis | rs9309473 | 1 | rs2421555 | chr2:73816955 | ALMS1P | chr2:73872046-73912692:+ | 0.56 | 6.59 | 6.68E-10 | Metabolite levels |
| UCEC | cis | rs10461617 | 1 | rs2432195 | chr5:56120413 | C5orf35 | chr5:56205103-56213010:+ | 0.56 | 6.23 | 4.26E-9 | Type 2 diabetes |
| UCEC | cis | rs9473555 | 1 | rs2448707 | chr6:49446951 | MUT | chr6:49398994-49431031:- | -0.34 | -5.63 | 8.58E-8 | Folate pathway vitamin levels |
| UCEC | cis | rs30187 | 1 | rs246454 | chr5:96123264 | ERAP1 | chr5:96096515-96149837:- | -0.45 | -5.59 | 1.03E-7 | Ankylosing spondylitis |